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Clinical trials

4370 results

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Palliative Care Needs of Children With Rare Diseases and Their Families

Study ID: NCT06938542
Start Date: 2026-02-02
End Date: 2030-01-31
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

480

Intervention / Treatment

Family Centered pediatric palliative care for family caregivers of children with rare diseases.

Sponsor

Children's National Research Institute

Source: clinicaltrials.gov

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VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway

Study ID: NCT06320951
Start Date: 2025-12-01
End Date: 2029-04-30
Study Type

Interventional

Study Phase

Phase2

No. of Participants

200

Intervention / Treatment

Vericiguat 10 MG

Placebo

Insulin Sensitivity Test

Resting Energy and Exercise Energy Expenditure Assessment

White Adipose Tissue Biopsy

MRI-PET Scan for Brown Adipose Tissue Volume Assessment

Sponsor

University of Alabama at Birmingham

Source: clinicaltrials.gov

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Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty

Study ID: NCT06951477
Start Date: 2025-10
End Date: 2027-12
Study Type

Observational

Study Phase

Not Applicable

No. of Participants

30

Intervention / Treatment

Revision Total Knee Arthroplasty

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Source: clinicaltrials.gov

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Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

Study ID: NCT06904066
Start Date: 2025-10-01
End Date: 2029-04-30
Study Type

Interventional

Study Phase

Phase1

No. of Participants

86

Intervention / Treatment

Aldesleukin

cyclophosphamide

fludarabine phosphate

Individual Patient TCR-Transduced PBL

TruSight Oncology (TSO) 500

Sponsor

National Cancer Institute (NCI)

Source: clinicaltrials.gov

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The Misoprostol-Only Regimen Evidence Study

Study ID: NCT07174856
Start Date: 2025-10-10
End Date: 2027-03
Study Type

Interventional

Study Phase

Phase4

No. of Participants

1900

Intervention / Treatment

Misoprostol-only medication abortion regimen

Combined regimen

Sponsor

Ibis Reproductive Health

Source: clinicaltrials.gov

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A Multi-Site Hybrid Type I Effectiveness-Implementation Randomized Trial of an Emergency Care Action Plan for Infants With Medical Complexity

Study ID: NCT06993129
Start Date: 2026-04-01
End Date: 2031-06-01
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

500

Intervention / Treatment

Emergency Care Action Plan

Sponsor

University of Vermont

Source: clinicaltrials.gov

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Persistence of Oral DNA Adducts in Smokers and Vapers

Study ID: NCT06983392
Start Date: 2026-01-31
End Date: 2030-07-30
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

150

Intervention / Treatment

Abstain from smoking/vaping

Sponsor

University of Minnesota

Source: clinicaltrials.gov

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Modulation of the Bone Immune Microenvironment Following Cabozantinib Treatment of Bone Metastatic Clear Cell Renal Cell Carcinoma: Proof of Concept Study

Study ID: NCT07187869
Start Date: 2026-03-31
End Date: 2029-04-07
Study Type

Interventional

Study Phase

Phase1

No. of Participants

16

Intervention / Treatment

Cabozantinib

Nivolumab

Sponsor

M.D. Anderson Cancer Center

Source: clinicaltrials.gov

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Short, Animated Storytelling (SAS) Video to Reduce Smartphone Addiction in the US

Study ID: NCT06979856
Start Date: 2025-10-19
End Date: 2025-12
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

6000

Intervention / Treatment

Short animated video

Informational Control

Sponsor

Stanford University

Source: clinicaltrials.gov

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ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

Study ID: NCT07173751
Start Date: 2025-10
End Date: 2030-09
Study Type

Interventional

Study Phase

Phase3

No. of Participants

558

Intervention / Treatment

Pumitamit

Nab-paclitaxel/Paclitaxel

Gemcitabine

Carboplatin

Eribulin

Matching placebo

Sponsor

BioNTech SE

Source: clinicaltrials.gov

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