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Clinical trials

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CA-4948 in Combination With Cisplatin, Gemcitabine, and Durvalumab in Patients With Untreated Advanced or Metastatic Biliary Tract Cancer

Study ID: NCT07107750
Start Date: 2025-10-31
End Date: 2031-12-31
Study Type

Interventional

Study Phase

Phase1

No. of Participants

48

Intervention / Treatment

CA-4948

Gemcitabine

Cisplatin

Durvalumab

Sponsor

Washington University School of Medicine

Source: clinicaltrials.gov

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Novel Delivery Method of Transgender Voice Therapy Using a Mobile Application

Study ID: NCT05815810
Start Date: 2025-11
End Date: 2026-12
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

50

Intervention / Treatment

Attuned: A mobile application

In-Person Voice Modification Therapy

Sponsor

Weill Medical College of Cornell University

Source: clinicaltrials.gov

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A Clinical Study of GeminiOne TEER System for the Treatment of Severe, Symptomatic MR.

Study ID: NCT07086534
Start Date: 2025-12-15
End Date: 2031-05-31
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

15

Intervention / Treatment

GeminiOne Transcatheter Edge-to-Edge Repair (TEER) System

Sponsor

Sierra Valve LLC

Source: clinicaltrials.gov

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Phase III Study of Topical Fibrinogen-Depleted Human Platelet Lysate Compared to Placebo for Moderate to Severe Dry Eye

Study ID: NCT06903611
Start Date: 2025-09-30
End Date: 2027-12
Study Type

Interventional

Study Phase

Phase3

No. of Participants

400

Intervention / Treatment

CAM-101

Vehicle Control

Sponsor

Cambium Bio Limited

Source: clinicaltrials.gov

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Intertransverse Process Block to Improve Quality of Recovery After Cardiac Surgery With Sternotomy

Study ID: NCT06926764
Start Date: 2025-11
End Date: 2027-11
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

100

Intervention / Treatment

Intertransverse process block

Sham Block

Levobupivacaine 0.25%

Sodium Chloride (NaCl) 0.9 %

Ultrasound guided injection with local anaestethic

Sponsor

Chinese University of Hong Kong

Source: clinicaltrials.gov

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Phase I Study of Allogeneic Transforming Growth Factor-beta Receptor Type 2 Knockout CD70 CAR NK Cells in Treatment Refractory Clear Cell Renal Cell Carcinoma

Study ID: NCT07072234
Start Date: 2026-01-01
End Date: 2030-02-01
Study Type

Interventional

Study Phase

Phase1

No. of Participants

30

Intervention / Treatment

Lymphodepleting chemotherapy

Dexamethasone

Fludarabine

Cyclophosphamate

Tgfbr-2 is CD70 Car NK

Sponsor

M.D. Anderson Cancer Center

Source: clinicaltrials.gov

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Intravenous Alpha-1 Antitrypsin for Hospitalized Patients With COPD Exacerbations (AECOPD Study)

Study ID: NCT07125664
Start Date: 2025-10-01
End Date: 2027-12-01
Study Type

Interventional

Study Phase

Phase2

No. of Participants

36

Intervention / Treatment

alpha1-proteinase inhibitor, produced from the plasma of human donors (Prolastin 1000 mg, powder and solvent for solution for infusion)

Placebo

Sponsor

IRCCS Policlinico San Matteo di Pavia Foundation

Source: clinicaltrials.gov

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Using MSCs for Chronic Active Antibody Mediated Rejection

Study ID: NCT07005687
Start Date: 2025-12-01
End Date: 2028-07-01
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

10

Intervention / Treatment

Stem Cells

Sponsor

Shahid Beheshti University of Medical Sciences

Source: clinicaltrials.gov

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Targeted Naltrexone to Support Individuals Participating in Dry January

Study ID: NCT07132177
Start Date: 2025-10-01
End Date: 2026-05-01
Study Type

Interventional

Study Phase

Phase2

No. of Participants

20

Intervention / Treatment

Naltrexone (oral tablets)

Sponsor

Brigham and Women's Hospital

Source: clinicaltrials.gov

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Hospital-to-Home Rehabilitation Through Exercise and Cognitive Training

Study ID: NCT07183241
Start Date: 2025-10
End Date: 2027-06
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

200

Intervention / Treatment

Physical exercise and cognitive exercises

Sponsor

Public University of Navarra

Source: clinicaltrials.gov

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