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NCT07480278 | RECRUITING | Postoperative Pain Management


mTLIP vs QIPB for Postoperative Analgesia in Lumbar Microdiscectomy Surgery
Sponsor:

Bursa City Hospital

Information provided by (Responsible Party):

Merih Yıldız Eglen

Brief Summary:

The aim of this prospective randomized clinical study is to compare the analgesic efficacy and side effects of modified thoracolumbar interfascial plane block and quadroiliac plane block applied preoperatively in patients undergoing lumbar microdiscectomy surgery.The study will include a total of 80 patients aged 18-65 years with ASA I-III, with 40 patients in each group( Group mTLIP and Group QIPB) undergoing lumbar microdiscectomy surgery. The primary objective of the study is to compare groups in terms of PCA opioid consumption during the 48-hour postoperative period. Secondary objectives are to compare groups in terms of QoR-15 recovery score, dynamic and static numerical rating scale scores, total rescue analgesic use, time to first request for rescue analgesia, length of hospital stay, block and opioid-related side effects and complications, and perioperative remifentanil infusion dose.

Condition or disease

Postoperative Pain Management

Intervention/treatment

Modified Thoracolumbar Interfascial Plane Block (mTLIP)

Quadro-Iliac Plane Block (QIPB)

Phase

NA

Detailed Description:

Lumbar spine surgery is commonly associated with moderate to severe postoperative pain . Inadequate pain control may lead to delayed mobilisation, increased cardiopulmonary complications, and prolonged hospital stay. Ultrasound-guided regional analgesia techniques, particularly fascial plane blocks, are increasingly used as part of multimodal analgesia in lumbar spine surgery. The thoracolumbar interfascial plane (TLIP) block is an established technique that provides effective analgesia and has been modified to improve its clinical application, resulting in the modified thoracolumbar interfascial plane (mTLIP) block. Previous studies have demonstrated the effectiveness of mTLIP for postoperative analgesia after lumbar spine surgeries. The quadro-iliac plane block (QIPB) is a recently described ultrasound-guided fascial plane block. Early reports suggest that QIPB may provide effective analgesia in lumbar spine procedures; however, comparative evidence with established techniques remains limited. This prospective randomized clinical trial aims to compare bilateral ultrasound-guided mTLIP and QIPB performed before the surgery in patients undergoing elective lumbar microdiscectomy surgery under general anesthesia, to evaluate whether QIPB can be considered a safe and effective alternative to mTLIP for postoperative analgesia.

Study Type : INTERVENTIONAL
Estimated Enrollment : 80 participants
Masking : DOUBLE
Primary Purpose : TREATMENT
Official Title : Comparison of Ultrasound-Guided Modified Thoracolumbar Interfascial Plane Block Versus Quadro-Iliac Plane Block for Postoperative Analgesia in Patients Undergoing Lumbar Microdiscectomy
Actual Study Start Date : 2026-03-25
Estimated Primary Completion Date : 2026-07-25
Estimated Study Completion Date : 2026-09-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 65 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Age between 18 and 65 years
  • * Classified as American Society of Anesthesiologists physical status I-III
  • * Scheduled for elective lumbar microdiscectomy surgery under general anesthesia
  • * Provision of written informed consent
Exclusion Criteria
  • * Use of anticoagulant medications or presence of bleeding diathesis
  • * Known allergy or hypersensitivity to local anesthetics or opioid drugs
  • * Infection at the planned block site
  • * Alcohol or drug dependence
  • * Cognitive impairment preventing reliable pain assessment
  • * Pregnancy or lactation
  • * History of previous lumbar spine surgery
  • * Diabetes mellitus
  • * Renal or hepatic insufficiency

mTLIP vs QIPB for Postoperative Analgesia in Lumbar Microdiscectomy Surgery

Location Details

NCT07480278


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Locations


RECRUITING

Turkey (Türkiye), Lotus

Bursa City Hospital

Bursa, Lotus, Turkey (Türkiye), 16110

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