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NCT07464080 | RECRUITING | Knee Osteoarthritis (Knee OA)

Advanced Brain Imaging-TKA (fMRI-TKA)
Sponsor:

Ottawa Hospital Research Institute

Brief Summary:

Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges. This study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.

Condition or disease

Knee Osteoarthritis (Knee OA)

Knee Pain Chronic

Brain Network Connectivity

Patient Satisfaction

Brain MRI

Intervention/treatment

fMRI Brain Scan

Phase

NA

Study Type : INTERVENTIONAL
Estimated Enrollment : 50 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : Brain Network-based Precision Medicine to Predict Dissatisfaction Following Total Knee Arthroplasty
Actual Study Start Date : 2026-04-01
Estimated Primary Completion Date : 2027-12-31
Estimated Study Completion Date : 2028-12-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. Male and female patients aged 18 years or older
  • 2. Primary TKA
  • 3. Diagnosis of osteoarthritis, inflammatory arthritis, or osteonecrosis
Exclusion Criteria
  • 1. Inability or refusal to sign informed consent form
  • 2. Non-English or French speaking, and no licensed translator, family member or substitute decision maker available
  • 3. History of major neurological disorders (e.g traumatic brain injury, epilepsy, multiple sclerosis
  • 4. Cognitive impairment or dementia
  • 5. Revision and/or Bilateral TKA
  • 6. Chronic Opioid use
Advanced Brain Imaging-TKA (fMRI-TKA)

Location Details

NCT07464080

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How to Participate

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Locations

RECRUITING

Canada, Ontario

The Ottawa Hospital

Ottawa, Ontario, Canada,