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NCT07232719 | RECRUITING | Obesity

A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
Sponsor:

Eli Lilly and Company

Brief Summary:

The purpose of this study is to evaluate the efficacy and safety of retatrutide compared with placebo for body weight reduction. Participation in the study will last about 65 weeks and may include about 18 visits.

Condition or disease

Obesity

Overweight

Intervention/treatment

Retatrutide

Placebo

Phase

PHASE3

Study Type : INTERVENTIONAL
Estimated Enrollment : 250 participants
Masking : DOUBLE
Primary Purpose : TREATMENT
Official Title : A Phase 3b Study to Investigate the Efficacy and Safety of Retatrutide Once Weekly in Participants Without Type 2 Diabetes Who Have Obesity or Overweight: A Randomized, Double-Blind, Placebo-Controlled Trial
Actual Study Start Date : 2025-11-17
Estimated Primary Completion Date : 2027-07
Estimated Study Completion Date : 2027-07

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Have a body mass index (BMI) of
    • * ≥30 kilogram per square meter (kg/m2) OR
    • * ≥27 kg/m2 with at least one of the following weight-related conditions: high blood pressure, abnormal levels of lipid, obstructive sleep apnea, heart disease
    • * Have at least one unsuccessful attempt to lose weight by dieting
    Exclusion Criteria
    • * Have a self-reported change in body weight \>5 kg (11 pounds) within 90 days before screening
    • * Have a prior or planned surgical treatment for obesity
    • * Have type 1 diabetes or type 2 diabetes
    • * Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
    • * Have had within the past 90 days before screening
    • * acute myocardial infarction
    • * cerebrovascular accident (stroke)
    • * hospitalization for unstable angina, or
    • * hospitalization due to congestive heart failure
    • * Have New York Heart Association Functional Classification Class IV congestive heart failure
    • * Have a history of chronic or acute pancreatitis
    • * Have taken weight loss drugs, including over-the counter medications within 90 days prior to screening
A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight

Location Details

NCT07232719

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, California

Artemis Institute for Clinical Research

Riverside, California, United States, 92503

ACTIVE NOT RECRUITING

United States, Florida

JEM Research Institute

Atlantis, florida, United States, 33462

ACTIVE NOT RECRUITING

United States, Florida

Headlands Research Orlando

Orlando, florida, United States, 32806

ACTIVE NOT RECRUITING

United States, Florida

Care Access - Tamarac

Tamarac, florida, United States, 33321

ACTIVE NOT RECRUITING

United States, Illinois

Care Access - Arlington Heights

Arlington Heights, Illinois, United States, 60005

ACTIVE NOT RECRUITING

United States, Kentucky

L-MARC Research Center

Louisville, Kentucky, United States, 40213

ACTIVE NOT RECRUITING

United States, Louisiana

IMA Clinical Research Monroe - Armand

Monroe, Louisiana, United States, 71201

RECRUITING

United States, Maryland

Pharmasite Research, Inc.

Baltimore, Maryland, United States, 21208

ACTIVE NOT RECRUITING

United States, Missouri

Clinical Research Professionals

Chesterfield, Missouri, United States, 63005

ACTIVE NOT RECRUITING

United States, Missouri

Clinvest Headlands Llc

Springfield, Missouri, United States, 65807

ACTIVE NOT RECRUITING

United States, New Jersey

IMA Clinical Research Warren

Warren Township, New Jersey, United States, 07059

ACTIVE NOT RECRUITING

United States, New York

IMA Clinical Research Manhattan

New York, New York, United States, 10036

ACTIVE NOT RECRUITING

United States, North Carolina

Trial Management Associates - Wilmington - Floral Parkway

Wilmington, North Carolina, United States, 28403

ACTIVE NOT RECRUITING

United States, Texas

Cedar Health Research

dallas, Texas, United States, 75251

ACTIVE NOT RECRUITING

United States, Texas

Headlands Research-El Paso

The Pass, Texas, United States, 79902

RECRUITING

United States, Texas

Cedar Health Research - Euless

Euless, Texas, United States, 76040

RECRUITING

United States, Texas

Cedar Health Research - Fort Worth

Fort Worth, Texas, United States, 76132

RECRUITING

United States, Texas

Care Access - Houston

Houston, Texas, United States, 77054

RECRUITING

United States, Texas

IMA Clinical Research San Antonio

Saint Anthony, Texas, United States, 78229

ACTIVE NOT RECRUITING

United Kingdom,

FutureMeds - Birmingham

Birmingham, United Kingdom, B21 9RY

ACTIVE NOT RECRUITING

United Kingdom,

Layton Medical Centre

Blackpool, United Kingdom, Once in a while

ACTIVE NOT RECRUITING

United Kingdom,

Bradford on Avon Health Centre

Bradford-on-Avon, United Kingdom, BA15 1DQ

ACTIVE NOT RECRUITING

United Kingdom,

FutureMeds - Liverpool

Bromborough, United Kingdom, Shatta fold

ACTIVE NOT RECRUITING

United Kingdom,

Cheadle Community Hospital

Cheadle, United Kingdom, ST10 1NS

ACTIVE NOT RECRUITING

United Kingdom,

HMC Health Group - Meadows Centre for Health

Hounslow, United Kingdom, TW4 7NR

ACTIVE NOT RECRUITING

United Kingdom,

St Bartholomew's Medical Centre

Oxford, United Kingdom, OX4 1XB

ACTIVE NOT RECRUITING

United Kingdom,

Atlantic Medical

Penzance, United Kingdom, TR18 3DX

ACTIVE NOT RECRUITING

United Kingdom,

The Adam Practice

Poole, United Kingdom, BH16 5PW

ACTIVE NOT RECRUITING

United Kingdom,

Woodstock Bower Surgery

Rotherham, United Kingdom, S61 1AH

ACTIVE NOT RECRUITING

United Kingdom,

Rame Group Practice

Torpoint, United Kingdom, PL11 2TB

ACTIVE NOT RECRUITING

United Kingdom,

Albany House Medical Centre

Wellingborough, United Kingdom, NN8 4RW