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NCT06954129 | NOT YET RECRUITING | Acute Kidney Injury

A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients
Sponsor:

University of Pennsylvania

Information provided by (Responsible Party):

Todd Miano

Brief Summary:

Hospitalized patients with suspected or confirmed infection are commonly treated with vancomycin (VN) in combination with either piperacillin-tazobactam (PT) or cefepime (CP). Although these regimens have similar effectiveness, recent observational evidence suggests they may differ in terms of the risk for acute kidney injury (AKI). Interpretation of existing evidence is complicated by the limitations of creatinine, the standard biomarker used to monitor kidney function, which has poor sensitivity and specificity for drug induced AKI. To address this important knowledge gap, the investigators propose to conduct a pragmatic, open-label, non-inferiority trial that will examine the comparative risk of AKI between these standard-of-care antibiotic combinations using sensitive and specific markers of drug-induced AKI. We hypothesize that the regimen of VN in combination with PT (VN+PT) is noninferior to the regimen of VN in combination with CP (VN+CP) in terms of AKI risk.

Condition or disease

Acute Kidney Injury

Intervention/treatment

Vancomycin

Piperacillin-tazobactam

Cefepime

Phase

PHASE4

Study Type : INTERVENTIONAL
Estimated Enrollment : 750 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : Markers of Nephrotoxicity During Treatment With Antibiotic Combinations: A Pragmatic Clinical Trial
Actual Study Start Date : 2025-10
Estimated Primary Completion Date : 2029-05
Estimated Study Completion Date : 2029-07

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. Age of at least 18 years
  • 2. Suspected or confirmed infection based on clinical criteria, for which vancomycin with piperacillin-tazobactam or vancomycin with cefepime was prescribed by the treating clinician, as evidenced by orders being placed in the electronic health record
  • 3. The treating clinician considers both vancomycin with piperacillin- tazobactam or vancomycin with cefepime as acceptable treatment
  • 4. The treating clinician anticipates at least 48 hours of antibiotic treatment
Exclusion Criteria
  • 1. Dialysis dependence or documented end stage kidney disease
  • 2. AKI at baseline
  • 3. Expected survival \<24 hours and/or presence of do not resuscitate orders
  • 4. History of antibiotic-resistant organisms (microbiological culture results showing bacterial isolates with resistant or intermediate susceptibility to any study drug within the prior 90 days)
  • 5. Documented allergy to vancomycin, cephalosporins, or penicillin
  • 6. Suspected central nervous system infection
  • 7. Inability to provide informed consent or lack of proxy for consent
  • 8. Prisoners/incarcerated individuals
  • 9. Known pregnancy or breastfeeding
  • 10. Previous enrollment in this study
  • 11. Receipt of vancomycin, piperacillin-tazobactam, or cefepime for \>24 hours within the preceding 7 days. At the time of screening, one-time doses of vancomycin, with or without piperacillin-tazobactam, or cefepime, will be allowed prior to randomization to avoid treatment delays; such patients must be enrolled within twelve hours of antibiotic administration.
A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients

Location Details

NCT06954129

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