Northwestern University
Sabra Abbott
The goal of this observational study is to characterize the pupil light response in patients with delayed sleep-wake phase disorder. A subset of participants will take part in a clinical trial to determine if increasing serotonin can alter the circadian response to light. The main questions it aims to answer is: Are there differences in the light response in patients with delayed sleep-wake phase disorder? Does citalopram increase melatonin suppression in patients with delayed sleep-wake phase disorder? Participants will complete activity and melatonin testing at home to determine their circadian timing. This will be followed by an eye test looking at the pupil response to different light stimuli. A subset of participants will complete two inpatient admissions where melatonin levels will be sampled and they will be exposed to a bright light. During one round of testing they will receive a placebo and in the other round of testing they will take a single dose of citalopram, a selective serotonin reuptake inhibitor.
Delayed Sleep-Wake Phase Disorder
Light and Citalopram
NA
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 220 participants |
| Masking : | NONE |
| Primary Purpose : | DIAGNOSTIC |
| Official Title : | Pupillometry in DSWPD Type 1 and Type 2 |
| Actual Study Start Date : | 2025-05-15 |
| Estimated Primary Completion Date : | 2029-02-28 |
| Estimated Study Completion Date : | 2029-08-31 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 16 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
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