Thinking of joining a study?

Register your interest

Become a volunteer?

NCT06948526 | NOT YET RECRUITING | Nonvital Primary Molars

Evaluation of Moringa Oleifera Leaf Extract Versus Sodium Hypochlorite in Pulpectomy of Nonvital Primary Molars
Sponsor:

Cairo University

Information provided by (Responsible Party):

Lama Hatam Food All

Brief Summary:

This randomized clinical trial aims to compare the clinical and radiographic success of Moringa Oleifera leaf extract with Sodium Hypochlorite as intracanal irrigants in pulpectomy of nonvital primary molars in children aged 3-7 years. The study evaluates both clinical parameters (pain, swelling, mobility) and radiographic healing (periapical changes, root resorption) over 12 months.

Condition or disease

Nonvital Primary Molars

Intervention/treatment

Moringa Oleifera Leaf Extract

Sodium Hypochlorite 1%

Phase

NA

Detailed Description:

Effective disinfection during pulpectomy of primary molars is essential for treatment success. Sodium hypochlorite is the gold standard intracanal irrigant but presents concerns regarding cytotoxicity and taste. Moringa Oleifera, a natural agent with antimicrobial, antioxidant, and anti-inflammatory properties, may offer a biocompatible alternative. This study is a parallel-design, randomized clinical trial evaluating 50 teeth in children aged 3-7 years. Patients will be randomly allocated to either 1% Sodium Hypochlorite or Moringa Oleifera leaf extract for intracanal irrigation. Clinical and radiographic outcomes will be assessed at 3, 6, and 12 months.

Study Type : INTERVENTIONAL
Estimated Enrollment : 50 participants
Masking : DOUBLE
Primary Purpose : TREATMENT
Official Title : Clinical and Radiographic Evaluation of Moringa Oleifera Leaf Extract Versus Sodium Hypochlorite as Intracanal Irrigations in Pulpectomy of Nonvital Primary Molars: A Randomized Clinical Trial
Actual Study Start Date : 2025-06-01
Estimated Primary Completion Date : 2026-06-01
Estimated Study Completion Date : 2026-08-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 3 Years to 7 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Cooperative children aged between 3-7 years
  • * Males/Females.
  • * Primary molars necessitating pulpectomy diagnosed with deep dental caries with pulp necrosis and periapical pathosis or both.
  • * Systemically healthy children
Exclusion Criteria
  • * Medically compromised and uncooperative children
  • * Tooth indicated for extraction due to root resorption more than two thirds of the root, teeth near exfoliation, deep subgingival caries hindering proper coronal seal.
  • * Mobile teeth (Miller's Grade 2 or more)
  • * Previous pulp therapy
Evaluation of Moringa Oleifera Leaf Extract Versus Sodium Hypochlorite in Pulpectomy of Nonvital Primary Molars

Location Details

NCT06948526

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

Egypt, Giza

Faculty of Dentistry, Cairo University

The-manual, Giza, Egypt, 12613