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NCT06936943 | RECRUITING | Richter's Transformation

ONO-4538 Study in Patients With Richter's Transformation
Sponsor:

Ono Pharmaceutical Co. Ltd

Brief Summary:

Investigate the efficacy and safety of ONO-4538 in patients with Richter's transformation

Condition or disease

Richter's Transformation

Intervention/treatment

ONO-4538

Phase

PHASE2

Study Type : INTERVENTIONAL
Estimated Enrollment : 14 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : A Multicenter, Open-label, Uncontrolled Study to Evaluate the Efficacy and Safety of ONO-4538 in Patients With Richter's Transformation
Actual Study Start Date : 2025-09
Estimated Primary Completion Date : 2029-07-31
Estimated Study Completion Date : 2030-07-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Diagnosis of diffuse large B-cell lymphoma (DLBCL)-type or Hodgkin lymphoma (HL)-type Richter's transformation
  • * In the case of DLBCL-type Richter's transformation, refractory, intolerant or ineligible for treatment of DLBCL
  • * Patients with measurable disease
  • * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
  • * Expected to survive for 90 days or more
Exclusion Criteria
  • * Serious complications
  • * Active multiple cancers
  • * Active central nervous system (CNS) disease
  • * History of allogeneic hematopoietic stem cell transplantation
ONO-4538 Study in Patients With Richter's Transformation

Location Details

NCT06936943

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

NOT YET RECRUITING

Japan, Hokkaido

Hokkaido University Hospital

Sapporo, Hokkaido, Japan, 060-8648

NOT YET RECRUITING

Japan, Tokyo

National Cancer Center Hospital

C goods Ku, Tokyo, Japan,

RECRUITING

Japan,

Kyusyu University Hospital

Fukuoka, Japan, 812-8582