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NCT06911229 | NOT YET RECRUITING | Parkinson Disease

Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
Sponsor:

University of Florida

Brief Summary:

Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

Condition or disease

Parkinson Disease

Intervention/treatment

Deep Brain Stimulation (DBS)

Phase

NA

Detailed Description:

We will test the hypotheses that DBS can facilitate split-belt walking adaptation with DBS ON compared with DBS OFF.

Study Type : INTERVENTIONAL
Estimated Enrollment : 60 participants
Masking : NONE
Primary Purpose : BASIC_SCIENCE
Official Title : Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
Actual Study Start Date : 2025-07-01
Estimated Primary Completion Date : 2028-12-31
Estimated Study Completion Date : 2028-12-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 80 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases;
  • * chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings;
  • * Age between 18 - 80 years old per the FDA data sheet for PD DBS;
  • * no dementia according to the clinical diagnostic criteria for PD dementia;
  • * ambulatory without the use of walking aids, or another person's assistance.
Exclusion Criteria
  • * other previous neurological surgery;
  • * suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.
Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Location Details

NCT06911229

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