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NCT06878131 | NOT YET RECRUITING | Colorectal Cancer

Precision-MRD: Prospective Observational Study of Biomarker-directed Systemic Therapy for Colorectal Cancer Patients With Minimal Residual Disease
Sponsor:

M.D. Anderson Cancer Center

Brief Summary:

The goal of this clinical research study is to learn about the effects of biomarkertargeted therapy on ctDNA in patrticipants with CRC and MRD. This is an observational study. Participants will be monitored while receiving biomarker-directed therapy that is determined by your treating oncologist (cancer doctor) per standard of care, independent of this study.

Condition or disease

Colorectal Cancer

Intervention/treatment

Colorectal Cancer

Detailed Description:

Primary Objective • To estimate the rate of ctDNA clearance at 6 months following initiation of biomarker-directed targeted therapy in colorectal cancer (CRC) participants with minimal residual disease (MRD). Secondary Objectives * To evaluate dynamics of ctDNA mutant allele fractions following initiation of biomarker-directed targeted therapy in MRD-positive CRC participants. * To estimate the rate of disease recurrence at 1 year following initiation of biomarker-directed targeted therapy in MRD-positive CRC participants.

Study Type : OBSERVATIONAL
Estimated Enrollment : 40 participants
Official Title : Precision-MRD: Prospective Observational Study of Biomarker-directed Systemic Therapy for Colorectal Cancer Patients With Minimal Residual Disease
Actual Study Start Date : 2025-09-30
Estimated Primary Completion Date : 2026-12-22
Estimated Study Completion Date : 2028-12-22

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Criteria
Inclusion Criteria
  • 1. Male or female subjects aged \> 18 years.
  • 2. Histologically or cytologically confirmed diagnosis of colorectal adenocarcinoma.
  • 3. Stage II-IV disease per current AJCC staging criteria with no definitive radiographic evidence of disease following locoregional treatment. Small indeterminate lesions measuring \< 10 mm may be permitted at the discretion of the principal investigator.
  • 4. Presence of one of the following targetable biomarkers on tumor or blood molecular testing: BRAF V600E mutation (Cohort A), KRAS G12C mutation (Cohort B), MSI-H status (Cohort C), and HER2 amplification (Cohort D).
  • 5. Positive ctDNA blood test obtained \> 21 days after surgery or last administration of adjuvant therapy.
  • 6. Prescribed one of the following standard-of-care targeted therapy regimens: BRAF V600E Inhibitor + anti-EGFR antibody for BRAF V600E-mutated tumors, KRAS G12C Inhibitor + anti-EGFR antibody for KRAS G12C-mutated tumors, anti-PD-1 antibody +/- anti-CTLA-4 antibody for MMRd/MSI-H tumors, or anti-HER2 therapies for HER2 amplified tumors.
    • Exclusion Criteria
  • 1. Prior exposure to the following classes of biomarker-directed therapies: BRAF V600E inhibitors, anti-EGFR antibodies, KRAS G12C inhibitors, anti-PD-1/PD-L1 antibodies, anti-CTLA-4 antibodies, or anti-HER2 therapies
  • 2. Presence of a concurrent malignancy requiring active treatment
  • 3. Inability to provide informed consent
  • 4. Children will not be enrolled in this study
  • 5. Pregnant women will not be enrolled in this study
  • 6. Cognitively Impaired subjects will not be enrolled in this study
    • Precision-MRD: Prospective Observational Study of Biomarker-directed Systemic Therapy for Colorectal Cancer Patients With Minimal Residual Disease

    Location Details

    NCT06878131

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    How to Participate

    Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

    Locations

    Not yet recruiting

    United States, Texas

    MD Anderson Cancer Center

    Houston, Texas, United States, 77030