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NCT06876662 | NOT YET RECRUITING | Chronic Lymphocytic Leukemia

A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma
Sponsor:

Eli Lilly and Company

Brief Summary:

Study J2N-MC-JZ01 (JZ01) is an individual-study appendix (ISA) under master protocol J2N-MC-JZNY, and represents participants from the completed originator study, clinical study LOXO-BTK-18001/J2N-OX-JZNA. Participants in the originator study will have the opportunity to continue their assigned study intervention or continue their follow-up visits by transitioning to this study. This study will evaluate the long-term safety and efficacy of pirtobrutinib.

Condition or disease

Chronic Lymphocytic Leukemia

Non-Hodgkin Lymphoma

Intervention/treatment

Pirtobrutinib

Phase

PHASE4

Study Type : INTERVENTIONAL
Estimated Enrollment : 279 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : Long-Term Safety of Pirtobrutinib in Participants From Study LOXO-BTK-18001 With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma
Actual Study Start Date : 2025-05
Estimated Primary Completion Date : 2030-05
Estimated Study Completion Date : 2032-12

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Are currently enrolled and active in the originator study, 18001. A participant is considered active in the study if they are
    • * receiving study intervention
    • * in the short-term follow-up period, or
    • * in the long-term follow-up period.
    Exclusion Criteria
    • * Were a participant in the Phase 1b cohort of Study 18001.
    • * Are pregnant or intend to become pregnant during the study or within 30 days of last dose of study treatment or intend to breastfeed during the study or within 1 week of the last dose of study treatment.
A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

Location Details

NCT06876662

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

United States, Florida

Sylvester Comprehensive Cancer Center

Miami, Florida, United States, 33136-1002

Not yet recruiting

United States, Florida

Florida Cancer Specialists

Sarasota, Florida, United States, 34232-6422

Not yet recruiting

United States, Georgia

The Emory Clinic

Atlanta, Georgia, United States, 30322-1013

Not yet recruiting

United States, Illinois

Northwestern University

Chicago, Illinois, United States, 60611-3013

Not yet recruiting

United States, Massachusetts

Dana-Farber Cancer Institute

Boston, Massachusetts, United States, 02115

Not yet recruiting

United States, Minnesota

Mayo Clinic- Minnesota

Rochester, Minnesota, United States, 55905

Not yet recruiting

United States, Nebraska

University Of Nebraska Medical Center

Omaha, Nebraska, United States, 69198

Not yet recruiting

United States, New York

Northwell Health

Lake Success, New York, United States, 11042-1118

Not yet recruiting

United States, New York

Memorial Sloan-Kettering Cancer Center (MSKCC) - New York

New York, New York, United States, 10065-6007

Not yet recruiting

United States, North Carolina

Duke University Medical Center

Durham, North Carolina, United States, 27710-4000

Not yet recruiting

United States, Ohio

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States, 43210-1063

Not yet recruiting

United States, Pennsylvania

University of Pennsylvania Hospital

Philadelphia, Pennsylvania, United States, 19104

Not yet recruiting

United States, Tennessee

Tennessee Oncology

Nashville, Tennessee, United States, 37203-2659

Not yet recruiting

United States, Texas

University of Texas MD Anderson Cancer Center

Houston, Texas, United States, 77030-4000

Not yet recruiting

United States, Washington

Swedish Cancer Institute

Seattle, Washington, United States, 98104-3588

Not yet recruiting

United States, Wisconsin

Medical College of Wisconsin

Milwaukee, Wisconsin, United States, 53226-3548

Not yet recruiting

Australia, South Australia

Flinders Medical Centre

Adelaide, South Australia, Australia, 5042

Not yet recruiting

Australia, Victoria

Peter MacCallum Cancer Centre

Melbourne, Victoria, Australia, 3000

Not yet recruiting

Australia,

Linear Clinical Research

Victoria, Australia, 3000

Not yet recruiting

France, Loire Atlantique

CHU de Nantes - Hotel Dieu

Nantes Cedex 1, Loire Atlantique, France, 44093

Not yet recruiting

Italy,

IRCCS-AOU Bologna-Policlinico S.Orsola-Malpighi

Bologna, Italy, 40138

Not yet recruiting

Italy,

San Raffaele Hospital

Milano, Italy, 20132

Not yet recruiting

Japan, Aichi-Prefecture

Nagoya Medical Center

Mr. Nagoya, Aichi-Prefecture, Japan, 4600001

Not yet recruiting

Japan, Kanagawa

Tokai University Hospital-Ishara Campus

Izhar, Kanagawa, Japan, 259-1193

Not yet recruiting

Japan, Tokyo

National Cancer Center Hospital

Chalk, Tokyo, Japan, 104-0045

Not yet recruiting

Japan,

National Hospital Organization Kyushu Cancer Center

Fukuoka, Japan, 811-1395

Not yet recruiting

Japan,

Tohoku University Hospital

Miyagi Prefecture, Japan, 9808574

Not yet recruiting

Japan,

Hokkaido University Hospital

Sapporo City, Japan, 060-8648

Not yet recruiting

Korea, Republic of, Korea

Seoul National University Hospital

Seoul, Korea, Korea, Republic of, 03080

Not yet recruiting

Korea, Republic of,

Samsung Medical Center

Seoul, Korea, Republic of, 06351

Not yet recruiting

Poland,

Winging MCM Krakow

Krakow, Poland, 30727

Not yet recruiting

Poland,

Institute of Hematology and Transfusion

Warsaw, Poland, 02-776

Not yet recruiting

United Kingdom, Devon

Derriford Hospital

Plymouth, Devon, United Kingdom, Plus pass

Not yet recruiting

United Kingdom, Oxfordshire

Churchill Hospital

Oxford, Oxfordshire, United Kingdom, As a solution

Not yet recruiting

United Kingdom, West Yorkshire

St James's University Hospital

Leeds, West Yorkshire, United Kingdom, LS9 7TF