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NCT06428630 | NOT YET RECRUITING | Oral Lichen Planus

Systemic Absorption of Dexamethasone Oral Rinse in Patients With Oral Lichen Planus
Sponsor:

Tufts University

Brief Summary:

The objective of this study is to see the amount of systemic absorption of a standard dose of dexamethasone oral rinse for patients with symptomatic oral lichen planus (OLP) or oral lichenoid reactions (OLR) and healthy subjects (those who do not have OLP or OLR aka the control group).

Condition or disease

Oral Lichen Planus

Oral Lichenoid Reaction

Intervention/treatment

dexamethasone oral rinse

Phase

EARLY_PHASE1

Study Type : INTERVENTIONAL
Estimated Enrollment : 20 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : Systemic Absorption of Dexamethasone Oral Rinse in Patients With Oral Lichen Planus
Actual Study Start Date : 2025-05-01
Estimated Primary Completion Date : 2026-09-01
Estimated Study Completion Date : 2027-09-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • 1. Over 18 years old
  • 2. Non-pregnant
  • 3. Newly diagnosed subjects with OLP/OLR. Definition of 'newly" in this case : new patient with complaint regarding oral erosions and ulceration, and diagnose clinically with OLP or OLR for the first time
  • 4. Those not exposed to topical or systemic corticosteroids for the previous 1 month. Meaning, those willing to not take this OLP/OLR treatment for 1 month before their visit
  • 5. Experimental group is clinically diagnosed with OLP/OLR
  • 6. Controls must have no history of OLP/OLR
Exclusion Criteria
  • 1 . Under 18 years old 2. Pregnant women 3. Recent history (\< than one month) of exposure to topical or systemic corticosteroids.
  • 4. History of advanced kidney, liver disease, or systemic fungal infection. 5. Corticosteroids hypersensitivity. 6. Active oral candidiasis 7. Patients on blood thinners medication ,anemic or suffer from bleeding disorders
Systemic Absorption of Dexamethasone Oral Rinse in Patients With Oral Lichen Planus

Location Details

NCT06428630

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How to Participate

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Locations

Not yet recruiting

United States, Massachusetts

Tufts University School of Dental Medicine

Boston, Massachusetts, United States, 02111