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NCT06310161 | RECRUITING | End Stage Renal Disease

Light Therapy in End Stage Kidney Disease
Sponsor:

University of Pennsylvania

Brief Summary:

The goal of this clinical trial is to test light therapy in patients with end stage kidney disease who are receiving hemodialysis. The main aim is to determine if light therapy decreases fatigue severity. Participants will receive light therapy using special glasses for one hour during the dialysis sessions for four weeks of treatment.

Condition or disease

End Stage Renal Disease

Intervention/treatment

Bright light

Dim Light

Phase

NA

Detailed Description:

In a single site, 2-arm (Bright Light Therapy group; Dim Light Group), parallel, randomized controlled trial we will enroll 60 subjects (n=30 per group) to assess the effects of Bright Light Therapy compared to Dim Light Therapy in subjects with end stage kidney disease who are receiving hemodialysis to treat fatigue. * To compare the effects of bright light therapy to dim light therapy on fatigue severity. * To explore the effects of bright light therapy to dim light therapy on salivary cortisol. * To compare the effects of bright light therapy to dim light therapy on insomnia, depression and quality of life. * To test the effects on bright light therapy to dim light therapy on physical activity levels.

Study Type : INTERVENTIONAL
Estimated Enrollment : 60 participants
Masking : TRIPLE
Primary Purpose : TREATMENT
Official Title : Bright Light Therapy to Treat Fatigue in End Stage Kidney Disease
Actual Study Start Date : 2026-02-01
Estimated Primary Completion Date : 2026-06-01
Estimated Study Completion Date : 2026-08-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. Signed informed consent prior to initiation of any study mandated procedure
  • 2. Male and female participants ≥ 18 years of age
  • 3. Diagnosis end stage kidney disease with hemodialysis 3 times/week for at least 1 month
  • 4. Fatigue Severity Scale (FSS) \> 9 at enrollment
  • 5. Home refrigerator for salivary cortisol storage
Exclusion Criteria
  • 1. Eye disorders: cataracts, glaucoma, retinal disorders (e.g. macular degeneration)
  • 2. Participants with photosensitivity (e.g. epilepsy)
  • 3. Hospitalized or acutely ill
    • Light Therapy in End Stage Kidney Disease

    Location Details

    NCT06310161

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    How to Participate

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    Locations

    RECRUITING

    United States, Pennsylvania

    University of Pennsylvania

    Philadelphia, Pennsylvania, United States, 19104