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NCT06220396 | RECRUITING | Healthy

CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study
Sponsor:

Mayo Clinic

Information provided by (Responsible Party):

Barry Borlaug

Brief Summary:

The purpose of this study is to evaluate pulmonary capillary wedge pressure (PCWP) and other hemodynamic measurements at rest and during exercise in healthy volunteers across the age spectrum.

Condition or disease

Healthy

Intervention/treatment

Right Heart Catheterization with Hemodynamics and Limited Echocardiogram

Magnetic Resonance Imaging (MRI)

Dual X-ray absorptiometry (DEXA) scan

Phase

NA

Study Type : INTERVENTIONAL
Estimated Enrollment : 80 participants
Masking : NONE
Primary Purpose : BASIC_SCIENCE
Official Title : CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study
Actual Study Start Date : 2026-01
Estimated Primary Completion Date : 2029-01
Estimated Study Completion Date : 2029-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 30 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * Apparently healthy volunteers are eligible to participate in this study if they are free of symptoms of exertional breathlessness or fatigue and any diagnosis of heart failure.
  • * Patients will also be required to have left ventricular ejection fraction (EF) ≥ 50%.
  • * Patients discovered to reduced EF or abnormal resting hemodynamics or other pathologic findings previously undiscovered will be considered screen failures and can be replaced by others to reach the goal enrollment.
  • * Informed consent were obtained.
  • * No history of heart failure.
  • * Willing and able to undergo invasive hemodynamic exercise testing, MRI, and other study assessments.
Exclusion Criteria
  • * Clinically significant symptoms of exertional dyspnea or fatigue in daily life in the opinion of the investigators.
  • * Any diagnosis of heart failure
  • * Symptomatic coronary artery disease (e.g., patients with chronic angina)
  • * Symptomatic valvular heart disease
  • * Pulmonary hypertension
  • * Cardiomyopathies
  • * High output heart failure
  • * Pericardial disease
  • * Clinically significant chronic lung disease in the opinion of the investigators
  • * Anemia (hemoglobin \<12 gm/dL in women and \<13 gm/dL in men)
  • * Estimated glomerular filtration rate ≤30mL/min
  • * Pregnant women
  • * Any other disorders or problems that would interfere with the ability to participate safely in the study (e.g. psychiatric disorder or substance abuse)
CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study

Location Details

NCT06220396

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Minnesota

Mayo Clinic in Rochester

Rochester, Minnesota, United States, 55905