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NCT05793567 | NOT YET RECRUITING | Myocardial Infarction

A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)
Sponsor:

Mayo Clinic

Information provided by (Responsible Party):

Claire E. Raphael

Brief Summary:

The purpose of this research is to find out if patients with Type 2 Myocardial Infarction (T2MI) without significant epicardial coronary artery disease (CAD) have a greater chance of having coronary microvascular disease (CMD).

Condition or disease

Myocardial Infarction

Coronary Microvascular Disease

Intervention/treatment

Coronary angiogram with coronary reactivity testing (CRT)

Study Type : OBSERVATIONAL
Estimated Enrollment : 52 participants
Official Title : Assessment of Microcirculatory Function in Type 2 Myocardial Infarction
Actual Study Start Date : 2025-07
Estimated Primary Completion Date : 2027-04
Estimated Study Completion Date : 2027-04

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Ability to give informed consent
  • * Structurally normal heart (normal LV and RV function, no more than mild valvular heart disease)
  • * For controls: atypical chest pain with indication for CMD testing
  • * For T2MI: meet criteria for T2MI according to the 4th Universal definition of MI (rise/fall of troponin with at least 1 value \>99th centile+ evidence of symptoms or signs of myocardial ischemia)
Exclusion Criteria
  • * Acute coronary event (evidence of plaque rupture, fissure or dissection on coronary angiogram)
  • * Known to have angiographically significant CAD/pressure wire positive for epicardial CAD
  • * Inability to receive heparin products
  • * Allergy/contraindication to acetylcholine/adenosine/nitroglycerine products
  • * Prior coronary artery bypass grafting
  • * Pregnancy (if sexually active woman of reproductive age, need negative pregnancy test prior to proceeding with coronary angiography - this is standard of care in cath lab)
  • * Asthma with prior ICU admission due to bronchospasm/need for invasive ventilation
A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)

Location Details

NCT05793567

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

United States, Minnesota

Mayo Clinic Rochester

Rochester, Minnesota, United States, 55905