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NCT04538976 | COMPLETED | Acute Exacerbation of COPD


Copd Exacerbation and Pulmonary Hypertension Trial
Sponsor:

Chronic Obstructive Pulmonary Disease Trial Network, Denmark

Brief Summary:

This trial will investigate whether patiens admitted with an acute exacerbation of chronic obstructive lung disease and pulmonary hypertension will benefit from a targeted pharmacological treatment.

Condition or disease

Acute Exacerbation of COPD

Intervention/treatment

Sildenafil

Phase

PHASE4

Detailed Description:

During admittance due to acute exacerbation of chronic obstructive lung disease will patience have an echocardiography to examine their pulmonary pressure. If patient have a tricuspidal return gradient above 40 mmHg, they will receive treatment with a phosphordiesterase-5-inhibitor, Sildenafil.

Study Type : INTERVENTIONAL
Estimated Enrollment : 250 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : Copd Exacerbation and Pulmonary Hypertension Trial
Actual Study Start Date : 2020-02-01
Estimated Primary Completion Date : 2024-03-15
Estimated Study Completion Date : 2024-03-15

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 40 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * COPD verified by specialist and spirometry
  • * Admitted with the diagnosis "acute exacerbation of COPD"
  • * TR-gradient ≥40 mmHg verified by specialist and echocardiography
  • * Informed consent
Exclusion Criteria
  • * Known pulmonal hypertension
  • * Known heart disease which affects the pump function of the heart
  • * Men \<40 years
  • * Women \<55 years
  • * Not-menopauseal women \<55 years (Menopause is defined as no menstruation within 12 months.)
  • * Severe mental illness which significantly complicates cooperation
  • * Severe language difficulties which significantly complicates cooperation
  • * known allergy to Sildenafil
  • * Sildenafil consumption ≥50 mg / week due to other indications

Copd Exacerbation and Pulmonary Hypertension Trial

Location Details

NCT04538976


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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations


Not yet recruiting

Denmark,

Bispebjerg University Hospital

Copenhagen, Denmark,

Not yet recruiting

Denmark,

Herlev-Gentofte Hospital

Copenhagen, Denmark,

Not yet recruiting

Denmark,

Hvidovre Hospital

Copenhagen, Denmark,

Not yet recruiting

Denmark,

North Zealand Hospital

Hillerød, Denmark,

Not yet recruiting

Denmark,

Odense University Hospital

Odense, Denmark,

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