Johns Hopkins University
This study will perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in disease stage. This includes disease progression in early stages of disease or disease regression with appropriate standard-of-care treatment.
Diabetic Retinopathy
Retinal Vein Occlusion
Hypertension,Essential
Retinal Vascular Disorder
Swept-Source (SS) OCT Angiography
Spectral-Domain (SD) OCT Angiography
Fundus Imaging
Axial Length Measurement Device
NA
The objective of this study is to perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in disease stage. This includes disease progression in early stages of disease or disease regression with appropriate standard-of-care treatment. Subjects will be identified from healthy subjects (seen for screening eye exams) and diseased subjects undergoing standard-of-care treatment or screening at eye clinic locations. The study population will include subjects with retinal vascular disease including but not limited to diabetic retinopathy, hypertension, retinal vein/arterial occlusion, and macular degeneration. Subjects who are enrolled will undergo non-invasive, minimal risk, FDA approved diagnostic imaging procedures to identify vascular changes. The study methods will include retrospective review and collection of clinically approved imaging data that is obtained through standard-of-care methods for subjects who meet inclusion and exclusion criteria. Subjects who are identified in this manner will be asked to participate in a prospective study by each clinical study site. The study end-points include the correlation of diagnostic imaging findings from Optical Coherence Tomography (OCT) based images with fundus photographs, clinical disease stage and visual acuity.
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 1050 participants |
| Masking : | SINGLE |
| Primary Purpose : | SCREENING |
| Official Title : | Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease |
| Actual Study Start Date : | 2019-10-01 |
| Estimated Primary Completion Date : | 2026-06-01 |
| Estimated Study Completion Date : | 2026-09-01 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years to 99 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: | 1 |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
Wilmer Eye Institute
Baltimore, Maryland, United States, 21287