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NCT03518073 | COMPLETED | Alzheimer Disease (AD)

A Study of LY3303560 in Participants With Early Symptomatic Alzheimer's Disease
Sponsor:

Eli Lilly and Company

Brief Summary:

The purpose of this study is to evaluate the safety and efficacy of a study drug that targets an abnormal protein in the brain found in people with Alzheimer's Disease (AD).

Condition or disease

Alzheimer Disease (AD)

Intervention/treatment

Zagotenemab

Placebo

Phase

PHASE2

Study Type : INTERVENTIONAL
Estimated Enrollment : 360 participants
Masking : TRIPLE
Primary Purpose : TREATMENT
Official Title : Assessment of Safety, Tolerability, and Efficacy of LY3303560 in Early Symptomatic Alzheimer's Disease
Actual Study Start Date : 2018-04-30
Estimated Primary Completion Date : 2021-08-23
Estimated Study Completion Date : 2021-10-25

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 60 Years to 85 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Participants must have gradual and progressive change in memory function for \>6 months.
  • * Participants must have a family member or close friend who is with you at least 10 hours per week and can attend study appointments.
Exclusion Criteria
  • * Participants must not have significant neurological disease affecting the nervous system, other than AD, that affects cognition or may affect completion of the study.
  • * Participants must not have serious or unstable illness that could interfere with the analysis of the study or has a life expectancy \<24 months.
  • * Participants must not have history of cancer within the last 5 years with the exception of certain types of skin, cervical, prostate, and other cancers that are not likely to recur or spread.
  • * Participants must not have serious risk for suicide.
  • * Participants must not have history of drug or alcohol use disorder within the last 2 years.
  • * Participants must not have multiple severe drug allergies
  • * Participants must not have HIV, Hepatitis B or Hepatitis C
  • * Participants must not be receiving gamma globulin (IgG) or intravenous immunoglobulin (IVIG) therapy
A Study of LY3303560 in Participants With Early Symptomatic Alzheimer's Disease

Location Details

NCT03518073

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

United States, Arizona

Banner Alzheimer's Institute

Phoenix, Arizona, United States, 85006

Not yet recruiting

United States, Arizona

Center for Neurosciences

Tucson, Arizona, United States, 85718

Not yet recruiting

United States, California

Pharmacology Research Institute

Encino, California, United States, 91316

Not yet recruiting

United States, California

Fullerton Neurology and Headache Center

Fullerton, California, United States, 92835

Not yet recruiting

United States, California

Irvine Clinical Research Center

Irvine, California, United States, 92614

Not yet recruiting

United States, California

Pharmacology Research Institute

The Alamitos, California, United States, 90720

Not yet recruiting

United States, California

National Research Institute - Huntington Park

Panorama City, California, United States, 91402

Not yet recruiting

United States, California

Anderson Clinical Research

Redlands, California, United States, 92374

Not yet recruiting

United States, California

Pacific Research Network

San Diego, California, United States, 92103

Not yet recruiting

United States, California

Univ of California San Francisco

San Francisco, California, United States, 94158

Not yet recruiting

United States, California

Syrentis Clinical Research

Santa Anna, California, United States, 92705

Not yet recruiting

United States, Connecticut

New England Institute for Clinical Research

Stamford, Connecticut, United States, 06905

Not yet recruiting

United States, Florida

JEM Research Institute

Atlantis, Florida, United States, 33462

Not yet recruiting

United States, Florida

Julie B. Schwartzbard, MD, PA

Aventura, Florida, United States, 33180

Not yet recruiting

United States, Florida

Quantum Laboratories Clinical Research

Deerfield Beach, Florida, United States, 33064

Not yet recruiting

United States, Florida

Brain Matters Research

Delray Beach, Florida, United States, 33445

Not yet recruiting

United States, Florida

Neuropsychiatric Research Center of Southwest Florida

Fort Myers, Florida, United States, 33912

Not yet recruiting

United States, Florida

Infinity Clinical Research, LLC

Hollywood, Florida, United States, 33024

Not yet recruiting

United States, Florida

Vin-Victor Faradji

Miami, Florida, United States, 33176

Not yet recruiting

United States, Florida

Renstar Medical Research

Ocala, Florida, United States, 34470

Not yet recruiting

United States, Florida

Bioclinica Inc

Orlando, Florida, United States, 32806

Not yet recruiting

United States, Florida

Progressive Medical Research

Port Orange, Florida, United States, 32127

Not yet recruiting

United States, Florida

Brain Matters Research

Stuart, Florida, United States, 34997

Not yet recruiting

United States, Florida

Infinity Clinical Research, LLC

Sunrise, Florida, United States, 33351

Not yet recruiting

United States, Georgia

Columbus Memory Center, PC

Columbus, Georgia, United States, 31909

Not yet recruiting

United States, Illinois

Great Lakes Clinical Trials

Chicago, Illinois, United States, 60640

Not yet recruiting

United States, Illinois

AMITA Health - Alexian Brothers Neurosciences Institute Clinical Research

Elk Grove Village, Illinois, United States, 60007

Not yet recruiting

United States, Indiana

Josephson Wallack Munshower Neurology, PC

Indianapolis, Indiana, United States, 46256

Not yet recruiting

United States, Kansas

Rowe Neurology Institute

Lenexa, Kansas, United States, 66214

Not yet recruiting

United States, Kansas

Cotton O'Neil Clinic

Stopy, Kansas, United States, 66606

Not yet recruiting

United States, Maryland

Pharmasite Research, Inc.

Baltimore, Maryland, United States, 21208

Not yet recruiting

United States, Massachusetts

Tufts Medical Center

Boston, Massachusetts, United States, 02111

Not yet recruiting

United States, Massachusetts

Boston Center for Memory

Newton, Massachusetts, United States, 02459

Not yet recruiting

United States, Missouri

Clinical Research Professionals

Chesterfield, Missouri, United States, 63005

Not yet recruiting

United States, New Jersey

The Cognitive and Research Center of New Jersey

Springfield, New Jersey, United States, 07081

Not yet recruiting

United States, New Jersey

Advanced Memory Research Institute of New Jersey

Toms River, New Jersey, United States, 08755

Not yet recruiting

United States, North Carolina

Raleigh Neurology Associates, P.A.

Raleigh, North Carolina, United States, 27607

Not yet recruiting

United States, North Carolina

PMG Research of Winston-Salem, LLC

Winston-Salem, North Carolina, United States, 27103

Not yet recruiting

United States, Ohio

Lindner Research Center

Cincinnati, Ohio, United States, 45219

Not yet recruiting

United States, Ohio

Ohio State University Medical Center

Columbus, Ohio, United States, 43210

Not yet recruiting

United States, Ohio

University of Cincinnati Health Neurology

Dayton, Ohio, United States, 45417

Not yet recruiting

United States, Pennsylvania

Lehigh Center for Clinical Research

Allentown, Pennsylvania, United States, 18104

Not yet recruiting

United States, Pennsylvania

Suburban Research Associates

Media, Pennsylvania, United States, 19063

Not yet recruiting

United States, Rhode Island

Butler Hospital

Providence, Rhode Island, United States, 02906

Not yet recruiting

United States, Texas

Baylor AT&T Memory Center

Dallas, Texas, United States, 75231

Not yet recruiting

United States, Texas

Neurology Consultants of Dallas, PA

Dallas, Texas, United States, 75243

Not yet recruiting

United States, Texas

Houston Methodist Research Ins

Houston, Texas, United States, 77030

Not yet recruiting

United States, Vermont

The Memory Clinic

Bennington, Vermont, United States, 05201

Not yet recruiting

United States, Virginia

Cognition Health

Fairfax, Virginia, United States, 22031

Not yet recruiting

Canada, Ca-on

Kawartha Centre - Redefining Healthy Aging

Peterborough, Ca-on, Canada, K9H 2P4

Not yet recruiting

Canada, Ontario

Toronto Memory Program

Toronto, Ontario, Canada, Paading

Not yet recruiting

Canada, Quebec

Outaouais memory clinic

Gauge, Quebec, Canada, J8t 8j1

Not yet recruiting

Canada, Quebec

NeuroSearch Developements

Greenfield Park, Quebec, Canada, J4V 2J2

Not yet recruiting

Canada, Quebec

Q&T Research Sherbrooke Inc.

Sherbrooke, Quebec, Canada, J1J 2g2

Not yet recruiting

Japan, Aichi

National Center for Geriatrics and Gerontology

Obu City, Aichi, Japan, 4748511

Not yet recruiting

Japan, Hyogo

Kobe City Medical Center General Hospital

Kobe, Hyogo, Japan, 650-0046

Not yet recruiting

Japan, Jp-13

Nippon Medical School Hospital

Tokyo, Jp-13, Japan, 113-8603

Not yet recruiting

Japan, Jp-26

National hospital Organization Utano National Hospital

Kyoto, Jp-26, Japan, 616-8255

Not yet recruiting

Japan, Jp-33

Katayama Medical Clinic

Kurashiki, Jp-33, Japan, 710-0813

Not yet recruiting

Japan, Kanagawa

Shonan Kamakura General Hospital

Kamakura, Kanagawa, Japan, 247-8533